A cryogenic three-beams microscope to track and isolate proteins for near-atomic resolution electron cryo-microscopy

Spearheaded by our colleague Jacob Hoogenboom at the Department of Imaging Physics (ImPhys), a research team comprising Jacob’s group and us, together with industry partners Delmic and Demcon-Kryoz will develop a novel cryogenic microscope (CRYO3BEAMS) in which a high-resolution light microscope is integrated with focused electron and ion beam systems to allow targeted extraction of specific proteins for high-resolution structural determination. The project builds on Jacob’s prior development of the SECOM platform now marketed by Delmic. See here for more information.

Schematic illustration of the working principle for the planned correlative CRYO3BEAMS cryo-microscope
Schematic illustration of the working principle for the planned correlative CRYO3BEAMS cryo-microscope