My name is Anna Daamen and I am a Nanobiology master student. The High Resolution Imaging course during my first year as a master student is what got me excited about electron microscopy, so in February I started my Master End Project in the Jakobi lab. During my project I will try to reconstitute the lipid modification of proteins in intracellular immunity in vitro and in vivo. The lipid modification of these proteins is what enables them to interact with the membrane and assemble in large molecular machineries. I will study their assemblies on liposomes and the interactions with the membrane using Cryo-EM.
Eva van Oosten
As a Nanobiology master student, I am doing my academic internship in the [Jakobi Lab]http://cryoem.tudelft.nl(). The group focuses on cellular auto-immunity, but the mechanisms the key proteins carry out are still quite unknown. Therefore I will look into the interactions between these proteins as this could give more insight in their different functions. I am curious to see what we will find out!
As part of my masters Nanobiology, I am doing my final project in the Jakobi lab. I will be working on the development of a new correlative imaging and nanomanipulation setup for cryo-EM sample preparation. With this setup, we will be able to investigate processes of cell-autonomous immunity in an entirely new way.
I am a Nanobiology student doing my MEP project in the Jakobi lab. I am interested in high-resolution imaging, image processing and data science. Therefore I took on the challenge to develop new methods that aim to utilize machine learning tools to automate data collection and analysis of electron diffraction data from macromolecular crystals. These tools will hopefully contribute to accelerating structural analysis of biomacromolecules using electron diffraction. When I am not analyzing data I like to play songs on my guitar or swim some lanes in the pool.
Angelique Biemans (September 2019 - November 2019)
Applied Physics student
I am a 3rd year bachelor student in Applied Physics and currently doing my final BEP project in the Jakobi lab. I am working on the data processing of electron diffraction patterns from crystals. From these patterns the orientation and structure of a crystal can be determined. In my project I try making data analysis of these patterns easier and more automated.
Amanda van der Sijs (September 2018 - July 2019)
I am a Nanobiology student doing my master thesis at Jakobi lab and Brouns lab. I will study recombinant phages with using cryo-EM and (hopefully!) resolve a high-resolution 3D structure of the phages to gain more insight into phage evolution. My project will consist of the optimization of the sample preparation, finding the best imaging technique and the image analysis of the microscopy data.
Lars van Roemburg (April 2019 - July 2019)
I’m a third year Nanobiology student and I’m doing my BEP at Jakobi Lab. I will be working on the contrast enhancement in the image analysis of the electron microscopy. The current program needs an initial atomic model for contrast enhancement and I will try to get rid of this. With this we could get a better look at proteins we don’t know anything of yet.
Floor Dolsma (April 2019 - July 2019)
Danilo Remmers (April 2019 - July 2019)
As a Nanobiology Bachelor’s student, I am working on my Bachelor End Project in the Jakobi Lab. I will be working on in vivo biotinylation of intracellular immune effectors. This will eventually enable me to study the interactions between these effectors in higher-order assemblies and to visualize these interactions using cryo-EM.
Nanobiology student (April 2018 - August 2018)
I am third year student in the Nanobiology program and I am currently doing my BEP in the Electron Nanoscopy group at the Bionanoscience department. In this project I will be working on faciltiating the interpretability of single particle cryo-EM maps by further developing local sharpening as implemented in the LocScale method.
Life Science and Technology student (April 2018 - August 2018)
I am currently in my third year of the Life Science & Technology program. For my BEP, I joined the Electron Nanoscopy group at the Kavli Institute in Delft. For this project, I will focus on the isolation and characterization of proteins involved in the cellular response against viral or bacterial attacks.